Electrophysiological phenotyping in genetically engineered mice
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Berul engineered mice Electrophysiological phenotyping in genetically
24 times a year (twice monthly) by the American Physiological Society, 9650 Rockville Pike, Bethesda MD systems with techniques linking genes and pathways to physiology, from prokaryotes to eukaryotes. It is published publishes results of a wide variety of studies from human and from informative model Physiological Genomics
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Advances in transgene and gene targeting technology have enabled sophisticated manipulation of the mouse genome, providing important insights into the molecular mechanisms underlying cardiac conduction, arrhythmogenesis, and sudden cardiac death. The mouse is currently the principal mammalian model for studying biological processes, particularly related to cardiac pathophysiology. Murine models...
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Considerable progress has been made in adapting existing and developing new technologies to enable increasingly detailed phenotypic information to be obtained in embryonic and newborn mice. Sophisticated methods for imaging mouse embryos and newborns are available and include ultrasound and magnetic resonance imaging (MRI) for in vivo imaging, and MRI, vascular corrosion casts, micro-computed t...
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There is evidence that genetic factors play a role in the complex multifactorial pathogenesis of hydrocephalus. Identification of the genes involved in the development of this neurologic disorder in animal models may elucidate factors responsible for the excessive accumulation of cerebrospinal fluid in hydrocephalic humans. The authors report here a brief summary of findings from 12 lines of ge...
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Introduction Genetically altered mice provide superb models of human physiology and disease. They allow us to evaluate the effects of single altered genes in the context of whole organism and provide tremendous insight into gene function. However, they can provide research results that are frequently unexpected, confusing or simply uninformative. The comparative pathologist is required to asses...
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ژورنال
عنوان ژورنال: Physiological Genomics
سال: 2003
ISSN: 1094-8341,1531-2267
DOI: 10.1152/physiolgenomics.00183.2002